Generac外观

詹姆斯汉高

詹姆斯汉高 詹姆斯汉高 生物学 副教授 电子邮件: 詹姆斯.henkel@ouggy.com 电话: 414.443.8735

詹姆斯汉高

教育

  • B.S., 生物学 from University of Wisconsin-Stevens Point - 2000
  • M.S., Clinical Microbiology from University of Wisconsin-La Crosse - 2003
  • Ph.D., Microbiology and Immunology from Medical College of Wisconsin, Wauwatosa - 2009
  • Postdoctoral ReSearch - Uniformed 服务s University of the Health Sciences (USUHS), 贝塞斯达, MD - 2012

Background

I grew up in rural central Wisconsin, and my heart is there still. I love being outdoors, ranging from gardening to hiking. 我是果园认证的, 7th-Dan Black Belt in Jidokwon Taekwondo, and regularly teach self-defense classes and Taekwondo classes. For those who have taken the CliftonStrengths analysis of your personality, I am one of the very rare “Woo” personalities in science. I am a Sci-Fi geek, a science nerd, and a rabid Packers fan. I experienced a set of severe illnesses in college caused by microbes, so I became very curious about what had made me so ill, igniting my interest in microbiology. My passion is microbiology and biochemistry, 但也显示了它有多复杂, 交织在一起, and awe-inspiring 生物学 and 生物化学 really are in nature. My wife has a doctorate in Performance Piano and Pedagogy, and has a very successful private studio. We have been blessed with three wonderful children. 

教学

  • BIO 143 Microbes Friends and Foes Lab
  • 生物课201生物导论
  • 微生物学基础
  • BIO 342临床微生物学 
  • 病原微生物学
  • bio321无脊椎动物学
  • bio322脊椎动物动物学
  • BIO 401/402研究策略
  • BCH 350生物化学
  • BCH 351生物化学实验室
  • PED 105跆拳道入门

研究兴趣

  • My main reSearch focus is to determine how Chlamydia can survive in mammalian host cells through small GTPase recruitment. Chlamydia trachomatis causes blindness world-wide and is more commonly known in the U.S. to be the leading cause of bacterial sexually-transmitted infections (STI). Chlamydia replicates by infecting mammalian cells and directing traffic of nutrients directly to the membrane-bound vesicle where the bacteria replicate, 叫做衣原体包涵体. Previous reSearch suggests that many of these trafficking and distribution orders come from small GTPases, a type of cellular protein switch which direct cellular components. Small GTPases such as RhoA and specific Rab proteins are shown to re-distribute to the Chlamydial Inclusion through an unknown mechanism. My reSearch investigates the mechanism by which RhoA and possibly other small GTPases interact with the Chlamydial inclusion. I am currently also reSearching vitamin availability in Chlamydial infections. This reSearch involves aspects of 生物化学, Cell 生物学, Molecular 生物学, and Microbiology.
  • 最近, I have started a collaboration with Anthropology and Chemistry faculty in examining human remains through multiple molecular and chemical means to collect detailed information on how the person lived and what infectious diseases they may have been exposed to during their lifetime. This resulted in a fascinating paper detailing a confirmation of syphilis and treatments for a person 100 years ago.
  • I regularly conduct reSearch in microbiology with interested and dedicated students. I also welcome the opportunity to work with students on aspects of microbial detection, 微生物生态学, 细菌毒素, 增长, 新陈代谢, and coral microbial disease reSearch. Very little prior experience is necessary - I train you, and work with you to develop a project that you will love to work on.

学术作品

论文

德国汉高J.S.戴维斯,J。.D.纽约州法利(Farley).W.  Anatomical and  biochemical evidence for 梅毒螺旋体 in a 19th to early twentieth century skeletal cadaver.  Forensic Science, Medicine and Pathology. 5月11日.

德国汉高J.S., 特普W.H.普泽德佩斯基,A.弗里茨,R.B.约翰逊,E.A.Barbieri, J.T. Subunit 疫苗 Efficacy against Botulinum Neurotoxin Subtypes. 2011. 疫苗. 8月9日. PMID: 21839134

德国汉高J.S., 鲍德温米.R., Barbieri J.T.  细菌毒素. 练习. 2010;100:1-29.  审查.

德国汉高J.S., 雅各布森,M.特普,W.码头,C.约翰逊,E.A.Barbieri, J.T. Catalytic Properties of Botulinum neurotoxins subtypes A3 and A4. 生物化学.

方宏,罗伟, 德国汉高J, 王志强,王志强. 2006. A yeast assay probes the interaction between botulinum neurotoxin serotype B and its SNARE substrate. 美国国家科学促进会. May2; 103 (18): 6958 - 63.

Meece J.K., 德国汉高J.S., 格拉泽L.里德·K.D. 2003. Mosquito surveillance for West Nile virus in southeastern Wisconsin-2002. 临床医学研究. 1月,1 (1):37-42.

里德K.D.米斯·J.K., 德国汉高J.S., 舒克拉年代.K. 2003. 鸟, migration and emerging zoonoses: West Nile virus, 莱姆病, 甲型流感和肠道病原体. 临床医学研究. 1月,1 (1):5 - 12.

以前的研究论文

University of Wisconsin-Stevens Point: Tick-bourne diseases in deer ticks from Nine-Mile State Forest, Wausau, WI

University of Wisconsin-La Crosse: Detection and surveillance of West Nile Virus in Wisconsin

Medical College of Wisconsin, Wauwatosa: Biochemical Characterization of Botulinum neurotoxin

Uniformed 服务s University of the Health Sciences (USUHS), 贝塞斯达, MD: Chlamydia trachomatis 新陈代谢 and small GTPase recruitment

服务

  • Youth ministry, Faith Lutheran, Sussex, WI
  • Volunteer teaching basic self-defense classes/series
  • Outside Civilian Scientist for Veteran Affairs of Milwaukee, Institutional Biosafety Committee

专业的会员

  • 美国微生物学会
  • 美国跆拳道联合会